John DePol (September 16, 1913 – December 13, 2004) was a New York printmaker and wood engraver. He was perhaps best known for his illustrations of the Benjamin Franklin keepsakes over a period of over 25 years.

Although John DePol is known as a master of wood engraving, he also produced prints by etching with aquatint and drypoint, as well as lithography. His earliest works were etchings with subjects taken from his life as a young man in New York City. Even these early works, done with almost no professional training, show DePol's sense of design, use of light and shadow, and his abiding interest in the lives of ordinary people. The University of Delaware Library holds the only known collection of DePol's early etchings.

Throughout his life, John DePol returned to the New York City of his birth for inspiration. Many of his earliest artwork was of the lower Manhattan neighborhood he grew up in. Over the years, he continued to make engravings of the buildings, skyline and neighborhoods of the city.